海马体损伤会破坏一种关联性失配过程。
Hippocampal lesions disrupt an associative mismatch process.
作者信息
Honey R C, Watt A, Good M
机构信息
School of Psychology, University of Wales, Cardiff CF1 3YG, United Kingdom.
出版信息
J Neurosci. 1998 Mar 15;18(6):2226-30. doi: 10.1523/JNEUROSCI.18-06-02226.1998.
Novel assays were used to assess inter alia whether the hippocampus is involved in detecting novelty per se or in an associative mismatch process. During training, rats received two audiovisual sequences (tone-left constant light and click-left flashing light). In both sham-operated control rats and those with excitotoxic hippocampal lesions, novel visual targets provoked an orienting response that habituated during training. Moreover, like sham-operated rats, rats with hippocampal lesions acquired associations between the elements of two audiovisual sequences. However, subsequent test trials in which the auditory stimuli preceding the visual targets were switched (click-left constant light and tone-left flashing light) provoked renewed orienting to the visual targets in sham-operated rats but not in hippocampal rats. These results support the view that hippocampal damage results in a failure to detect (or act on) mismatches that are generated when an auditory stimulus associatively evokes the memory of one visual stimulus and a different (familiar) visual stimulus is present in the environment.
新型检测方法尤其用于评估海马体是否参与检测新奇事物本身或关联失配过程。在训练期间，大鼠接受两个视听序列（音调 - 左侧恒定光和咔哒声 - 左侧闪烁光）。在假手术对照大鼠和患有兴奋性毒性海马损伤的大鼠中，新颖的视觉目标都会引发一种定向反应，该反应在训练过程中会逐渐习惯化。此外，与假手术大鼠一样，患有海马损伤的大鼠也能在两个视听序列的元素之间建立关联。然而，在随后的测试试验中，将视觉目标之前的听觉刺激进行切换（咔哒声 - 左侧恒定光和音调 - 左侧闪烁光），这在假手术大鼠中引发了对视觉目标的重新定向，但在海马损伤大鼠中却没有。这些结果支持了这样一种观点，即海马损伤会导致无法检测到（或对其做出反应）当一个听觉刺激关联唤起一个视觉刺激的记忆而环境中出现不同（熟悉）视觉刺激时产生的失配。
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