生长锥信号传导中对接衔接蛋白的结构域要求。
Domain requirements for the Dock adapter protein in growth- cone signaling.
作者信息
Rao Y, Zipursky S L
机构信息
Department of Biological Chemistry, Molecular Biology Institute, The School of Medicine, University of California, Los Angeles, CA 90095-1662, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2077-82. doi: 10.1073/pnas.95.5.2077.
Abstract
Tyrosine phosphorylation has been implicated in growth-cone guidance through genetic, biochemical, and pharmacological studies. Adapter proteins containing src homology 2 (SH2) domains and src homology 3 (SH3) domains provide a means of linking guidance signaling through phosphotyrosine to downstream effectors regulating growth-cone motility. The Drosophila adapter, Dreadlocks (Dock), the homolog of mammalian Nck containing three N-terminal SH3 domains and a single SH2 domain, is highly specialized for growth-cone guidance. In this paper, we demonstrate that Dock can couple signals in either an SH2-dependent or an SH2-independent fashion in photoreceptor (R cell) growth cones, and that Dock displays different domain requirements in different neurons.
摘要
通过遗传学、生物化学和药理学研究表明，酪氨酸磷酸化与生长锥导向有关。含有src同源2（SH2）结构域和src同源3（SH3）结构域的衔接蛋白提供了一种将通过磷酸酪氨酸的导向信号与调节生长锥运动的下游效应器联系起来的方式。果蝇衔接蛋白Dreadlocks（Dock）是哺乳动物Nck的同源物，含有三个N端SH3结构域和一个单一的SH2结构域，在生长锥导向方面具有高度特异性。在本文中，我们证明Dock可以在光感受器（R细胞）生长锥中以SH2依赖性或SH2非依赖性方式耦合信号，并且Dock在不同神经元中表现出不同的结构域需求。
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