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Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes.
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The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.
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The promotion of V region hypermutation.
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Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation.
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Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches.
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