Friedman B H, Thayer J F
Department of Psychology, Washington University, St. Louis, Missouri, USA.
J Psychosom Res. 1998 Jan;44(1):133-51. doi: 10.1016/s0022-3999(97)00202-x.
The analysis of heart rate variability (HRV) is becoming widely used in clinical research to provide a window into autonomic control of HR. This technique has been valuable in elucidating the autonomic underpinnings of panic disorder (PD), a condition that is marked by reports of heart palpitations. A body of research has emerged that implicates a relative reduction in HRV and cardiac vagal tone in PD, as indicated by various HRV measures. These data are consistent with the cardiac symptoms of panic attacks, as well as with developmental evidence that links high vagal tone with enhanced attention, effective emotion regulation, and organismic responsivity. Implications of these findings for nosology and pathophysiology are discussed. Reports of reduced HRV in PD contrast with portrayals of excess autonomic lability in anxiety. This contradiction is addressed in the context of traditional homeostatic models versus a systems perspective that views physiologic variability as essential to overall stability.
心率变异性（HRV）分析在临床研究中得到广泛应用，为了解心率的自主控制提供了一个窗口。这项技术在阐明惊恐障碍（PD）的自主神经基础方面很有价值，惊恐障碍的特征是有心悸报告。已经出现了一系列研究，表明通过各种HRV测量方法，PD患者的HRV和心脏迷走神经张力相对降低。这些数据与惊恐发作的心脏症状一致，也与将高迷走神经张力与注意力增强、有效的情绪调节和机体反应性联系起来的发育证据一致。讨论了这些发现对疾病分类学和病理生理学的意义。PD患者HRV降低的报告与焦虑症中自主神经不稳定过度的描述形成对比。在传统的稳态模型与将生理变异性视为整体稳定性必不可少的系统观点的背景下，解决了这一矛盾。
