强直性肌营养不良患者中缝核含5-羟色胺神经元的缺失：一项定量免疫组织化学研究及其与睡眠过多的关系。

Loss of serotonin-containing neurons in the raphe of patients with myotonic dystrophy: a quantitative immunohistochemical study and relation to hypersomnia.

作者信息

Ono S, Takahashi K, Jinnai K, Kanda F, Fukuoka Y, Kurisaki H, Mitake S, Inagaki T, Yamano T, Nagao K

机构信息

Department of Neurology, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan.

出版信息

Neurology. 1998 Feb;50(2):535-8. doi: 10.1212/wnl.50.2.535.

DOI:10.1212/wnl.50.2.535

PMID:9484393

Abstract

Hypersomnia occurs frequently in patients with myotonic dystrophy (MyD). We performed a quantitative immunohistochemical study of serotonin (5-HT)-containing neurons linked to hypersomnia in the dorsal raphe nucleus (DRN) and the superior central nucleus (SCN) in 8 patients with MyD, 5 of whom showed hypersomnia, and in 12 age-matched controls. The densities of 5-HT neurons in the DRN and the SCN were significantly lower in MyD patients with hypersomnia than in MyD patients without hypersomnia and controls. These data suggest that the loss of 5-HT neurons of the DRN and the SCN is associated with the presence of hypersomnia in MyD.

摘要

发作性睡病在强直性肌营养不良（MyD）患者中频繁出现。我们对8例MyD患者（其中5例有发作性睡病）和12例年龄匹配的对照者进行了一项定量免疫组化研究，以观察与发作性睡病相关的中缝背核（DRN）和中央上核（SCN）中含5-羟色胺（5-HT）的神经元。与无发作性睡病的MyD患者及对照者相比，有发作性睡病的MyD患者DRN和SCN中5-HT神经元的密度显著降低。这些数据表明，DRN和SCN中5-HT神经元的缺失与MyD患者发作性睡病的存在有关。