Ono S, Kanda F, Takahashi K, Fukuoka Y, Jinnai K, Kurisaki H, Mitake S, Inagaki T, Nagao K
Department of Neurology, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan.
Acta Neuropathol. 1995;89(2):122-5. doi: 10.1007/BF00296355.
A quantitative study of neurons in the dorsal raphe nucleus (DRN) and the superior central nucleus (SCN) was performed in seven patients with myotonic dystrophy (MyD), five of whom showed hypersomnia, and in eight age-matched controls. The densities of neurons in the DRN and the SCN were significantly lower in MyD patients with hypersomnia than in MyD patients without hypersomnia and control subjects. There was an appreciable positive correlation in the density of neurons between the DRN and the SCN in all MyD patients. These data suggest that the neuronal loss of the DRN and the SCN is associated with the presence of hypersomnia in MyD.
对7例肌强直性营养不良（MyD）患者（其中5例表现为嗜睡）和8例年龄匹配的对照者的中缝背核（DRN）和中央上核（SCN）中的神经元进行了定量研究。与无嗜睡的MyD患者及对照者相比，有嗜睡症状的MyD患者DRN和SCN中的神经元密度显著降低。在所有MyD患者中，DRN和SCN的神经元密度之间存在明显的正相关。这些数据表明，DRN和SCN的神经元丢失与MyD患者嗜睡的存在有关。
