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小细胞肺癌患者中人类白细胞抗原与抗Hu综合征之间无关联。

Lack of association between human leukocyte antigens and the anti-Hu syndrome in patients with small-cell lung cancer.

作者信息

Uchuya M, Fleury A, Graus F, Costagliola D, Liblau R, Merle-Beral H, Théodorou I, Delattre J Y

机构信息

Department of Neurology, Hôpital de la Salpêtrière, Paris, France.

出版信息

Neurology. 1998 Feb;50(2):565-6. doi: 10.1212/wnl.50.2.565.

DOI:10.1212/wnl.50.2.565
PMID:9484403
Abstract

We compared the human leukocyte antigen alleles found in a group of 17 patients with small-cell lung cancer (SCLC), paraneoplastic neurologic syndromes (PNS), and high titers of anti-Hu autoantibodies with those in 30 patients with SCLC but no PNS and no anti-Hu antibodies (control group). There was no difference between the two groups, suggesting that specific haplotypes are not required for the development of the "anti-Hu syndrome."

摘要

我们比较了一组17例患有小细胞肺癌(SCLC)、副肿瘤性神经综合征(PNS)且抗Hu自身抗体滴度高的患者与30例患有SCLC但无PNS且无抗Hu抗体的患者(对照组)中发现的人类白细胞抗原等位基因。两组之间没有差异,这表明“抗Hu综合征”的发生不需要特定的单倍型。

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Lack of association between human leukocyte antigens and the anti-Hu syndrome in patients with small-cell lung cancer.小细胞肺癌患者中人类白细胞抗原与抗Hu综合征之间无关联。
Neurology. 1998 Feb;50(2):565-6. doi: 10.1212/wnl.50.2.565.
2
Lack of association between human leukocyte antigens and anti-Hu syndrome in patients with small-cell lung cancer.小细胞肺癌患者中人类白细胞抗原与抗Hu综合征之间不存在关联。
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Immunopathogenesis of paraneoplastic neurological syndromes associated with anti-Hu antibodies: A beneficial antitumor immune response going awry.
与抗Hu抗体相关的副肿瘤性神经综合征的免疫发病机制:有益的抗肿瘤免疫反应出现偏差。
Oncoimmunology. 2013 Dec 1;2(12):e27384. doi: 10.4161/onci.27384. Epub 2013 Dec 10.