Puius Y A, Mahoney N M, Almo S C
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Curr Opin Cell Biol. 1998 Feb;10(1):23-34. doi: 10.1016/s0955-0674(98)80083-5.
Filamentous actin structures possess unique biophysical and biochemical properties and are required for cell locomotion, cell division, compartmentalization and morphological processes. The site-specific assembly and disassembly of these structures are directed by actin-regulatory proteins. This article reviews how structural studies are now defining the atomic details of small modular domains present in actin-regulatory proteins responsible for crosslinking, severing and capping of actin filaments, as well as for localization of actin filament assembly. These studies have identified three modular strategies for the design of proteins that regulate the actin cytoskeleton.
丝状肌动蛋白结构具有独特的生物物理和生化特性，是细胞运动、细胞分裂、区室化和形态形成过程所必需的。这些结构的位点特异性组装和解聚由肌动蛋白调节蛋白指导。本文综述了结构研究如何确定肌动蛋白调节蛋白中负责肌动蛋白丝交联、切断和封端以及肌动蛋白丝组装定位的小模块化结构域的原子细节。这些研究确定了三种设计调节肌动蛋白细胞骨架的蛋白质的模块化策略。
