IgA肾病患者尿液中单核细胞趋化蛋白（MCP）-1水平与疾病活动度
Urinary levels of monocyte chemoattractant protein (MCP)-1 and disease activity in patients with IgA nephropathy.
作者信息
Saitoh A, Suzuki Y, Takeda M, Kubota K, Itoh K, Tomino Y
机构信息
Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
出版信息
J Clin Lab Anal. 1998;12(1):1-5. doi: 10.1002/(sici)1098-2825(1998)12:1<1::aid-jcla1>3.0.co;2-f.
Abstract
Using a quantitative sandwich ELISA, we studied 17 patients with IgA nephropathy to determine if levels of urinary monocyte chemoattractant protein-1 (MCP-1) might reflect the disease activity. The levels of urinary MCP-1 in patients with the advanced stage were significantly higher than those in patients with the mild stage of the disease, or in healthy controls. The results showed a significant correlation between the levels of urinary MCP-1 and the disease activity, i.e., levels of urinary casts and urinary protein. It was thus suggested that the measurement of urinary MCP-1 is useful in evaluating the degree of renal injuries and/or prognosis in patients with IgA nephropathy.
摘要
我们使用定量夹心酶联免疫吸附测定法，对17例IgA肾病患者进行研究，以确定尿单核细胞趋化蛋白-1（MCP-1）水平是否可能反映疾病活动度。疾病晚期患者的尿MCP-1水平显著高于疾病轻度阶段患者或健康对照者。结果显示，尿MCP-1水平与疾病活动度（即尿沉渣和尿蛋白水平）之间存在显著相关性。因此表明，测定尿MCP-1有助于评估IgA肾病患者的肾损伤程度和/或预后。
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