与开角型青光眼相关的视神经乳头的衰老变化
Aging changes of the optic nerve head in relation to open angle glaucoma.
作者信息
Garway-Heath D F, Wollstein G, Hitchings R A
机构信息
Glaucoma Unit, Moorfields Eye Hospital, London.
出版信息
Br J Ophthalmol. 1997 Oct;81(10):840-5. doi: 10.1136/bjo.81.10.840.
AIMS
To determine the age related changes in optic nerve head structure in a group of normal subjects and assess the significance of any changes in relation to those found in open angle glaucoma.
METHODS
A group of 88 white volunteers and friends and spouses of patients with a normal visual field and normal intraocular pressure was studied. Two different imaging and measurement devices were used (computer assisted planimetry and scanning laser ophthalmoscopy), and the results from each were compared. Measurements were made of the optic disc, optic cup, and neuroretinal rim areas, and the vertical optic disc diameter and cup/disc diameter ratio.
RESULTS
Neuroretinal rim area declined at the rate of between 0.28% and 0.39% per year. Vertical optic cup diameter and optic cup area increased with age. The mean cup/disc diameter ratio increased by about 0.1 between the ages of 30 and 70 years.
CONCLUSIONS
Age related changes are significant and measurable, and should be taken into account when assessing the glaucoma suspect, and when estimating the rate of progression of glaucomatous optic neuropathy in patients with established disease.
目的
确定一组正常受试者视神经乳头结构的年龄相关变化，并评估与开角型青光眼患者所发现的变化相关的任何改变的意义。
方法
对88名视野正常、眼压正常的白人志愿者以及患者的朋友和配偶进行了研究。使用了两种不同的成像和测量设备（计算机辅助平面测量法和扫描激光检眼镜），并对每种设备的结果进行了比较。对视盘、视杯和神经视网膜边缘区域进行了测量，以及垂直视盘直径和杯盘直径比。
结果
神经视网膜边缘区域每年以0.28%至0.39%的速度下降。垂直视杯直径和视杯面积随年龄增长而增加。在30岁至70岁之间，平均杯盘直径比增加了约0.1。
结论
年龄相关变化显著且可测量，在评估青光眼可疑患者以及估计已确诊疾病患者青光眼性视神经病变的进展速度时应予以考虑。
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