Shah I A, Jayram L, Gani O S, Fox I S, Stanley T M
Department of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Phoenix, Arizona 85012, USA.
Cancer. 1998 Mar 1;82(5):860-6. doi: 10.1002/(sici)1097-0142(19980301)82:5<860::aid-cncr9>3.0.co;2-n.
Papillary serous carcinoma of the peritoneum (PSCP) is a rare primary peritoneal tumor, described exclusively in women. It is believed to arise from the secondary müllerian system, which is comprised of the pelvic and lower abdominal mesothelial lining and subjacent (subcoelomic) mesenchyme in women. Both mesotheliomas and PSCP arise from the coelomic epithelium, but are clinicopathologically and biologically distinct entities.
The authors report clinicopathologic findings in a man, age 74 years, who died 3 months after the diagnosis of an extensive malignant abdominal disease.
The routine histologic and immunocytochemical studies of tumor tissue, obtained during the patient's lifetime and at autopsy, validated the unique occurrence of PSCP in a man.
This case illustrates that PSCP can occur in a man and that this diagnosis may be considered in the differential diagnosis of papillary serous tumors of the peritoneum in male patients. Although rare, PSCP is a diagnostically distinct entity the treatment of which is similar to ovarian serous tumors rather than mesotheliomas.
腹膜乳头状浆液性癌（PSCP）是一种罕见的原发性腹膜肿瘤，仅在女性中有所描述。它被认为起源于副苗勒系统，该系统在女性中由盆腔和下腹部间皮衬里及下方（体腔下）间充质组成。间皮瘤和PSCP均起源于体腔上皮，但在临床病理和生物学方面是不同的实体。
作者报告了一名74岁男性的临床病理结果，该男性在被诊断为广泛的恶性腹部疾病3个月后死亡。
在患者生前及尸检时获取的肿瘤组织进行的常规组织学和免疫细胞化学研究，证实了PSCP在男性中的独特发生。
该病例表明PSCP可发生于男性，在男性患者腹膜乳头状浆液性肿瘤的鉴别诊断中可考虑这一诊断。尽管罕见，但PSCP是一种诊断上独特的实体，其治疗与卵巢浆液性肿瘤相似，而非间皮瘤。
