Fritsch C, Goerz G, Ruzicka T
Department of Dermatology, Heinrich-Heine-University, Düsseldorf, Germany.
Arch Dermatol. 1998 Feb;134(2):207-14. doi: 10.1001/archderm.134.2.207.
Photodynamic therapy (PDT) uses exogenously administered or endogenously formed photosensitizers activated by light to induce cell death via formation of singlet oxygen and other free radicals. Photodynamic therapy is increasingly used for the treatment of skin cancers and other indications. The efficacy of PDT depends on the structure of the photosensitizer, the administration modality, the light source, and the treatment procedure. We reviewed the most recent clinical and experimental developments in PDT research related to dermatology. The substrate under most intense investigation in PDT research is delta-aminolevulinic acid (ALA). Photodynamic therapy with topically applied ALA has been shown to be highly efficient in the treatment of cutaneous neoplasms by using intralesionally formed porphyrins as photosensitizers. For solar keratoses, best response rates have been described. delta-Aminolevulinic-PDT is also efficient in the treatment of superficial basal cell and squamous cell carcinomas. In addition, the fluorescence of ALA-induced porphyrins under a Wood light is highly selective in neoplastic cutaneous tissue and offers a useful technique in detecting and delineating skin tumors with ill-defined borders.
光动力疗法（PDT）利用外源性给予或内源性形成的光敏剂，通过光照激活，经单线态氧和其他自由基的形成诱导细胞死亡。光动力疗法越来越多地用于治疗皮肤癌和其他适应症。光动力疗法的疗效取决于光敏剂的结构、给药方式、光源和治疗程序。我们回顾了与皮肤科相关的光动力疗法研究的最新临床和实验进展。光动力疗法研究中最受关注的底物是δ-氨基乙酰丙酸（ALA）。通过局部应用ALA进行光动力疗法，利用皮损内形成的卟啉作为光敏剂，已被证明在治疗皮肤肿瘤方面非常有效。对于日光性角化病，已有最佳有效率的报道。δ-氨基乙酰丙酸光动力疗法在治疗浅表基底细胞癌和鳞状细胞癌方面也很有效。此外，在伍德灯下，ALA诱导的卟啉荧光在皮肤肿瘤组织中具有高度选择性，为检测和勾勒边界不清的皮肤肿瘤提供了一种有用的技术。
