Wolf P, Rieger E, Kerl H
Department of Dermatology, University of Graz, Austria.
J Am Acad Dermatol. 1993 Jan;28(1):17-21. doi: 10.1016/0190-9622(93)70002-b.
Topical photodynamic therapy with endogenous porphyrins consists of irradiation of a tumor with visible light after the application of exogenous 5-aminolevulinic acid.
To assess the effectiveness of this modality, patients with precancerous conditions and various skin cancers were treated.
Thirteen patients with 70 skin lesions were enrolled. Standard treatment involved the topical application of 20% 5-aminolevulinic acid in an oil-in-water emulsion. The emulsion was applied under an occlusive dressing for 4 to 8 hours before exposure to photoactivating light.
We observed a complete response after a single treatment for all 9 solar keratoses, 5 of 6 early invasive squamous cell carcinomas, and 36 of 37 superficial basal cell carcinomas. Only 1 of 10 nodulo-ulcerative basal cell carcinomas completely resolved. Eight cutaneous metastases of malignant melanoma were therapeutic failures.
Topical photodynamic therapy with endogenous porphyrins is effective for superficial epithelial skin tumors.
内源性卟啉光动力疗法是在外源性5-氨基乙酰丙酸应用后，用可见光照射肿瘤。
为评估这种治疗方式的有效性，对癌前病变和各种皮肤癌患者进行了治疗。
纳入13例患者，共70处皮肤损害。标准治疗包括在水包油乳剂中局部应用20%的5-氨基乙酰丙酸。在暴露于光激活光之前，将乳剂在封闭敷料下涂抹4至8小时。
我们观察到，所有9例日光性角化病、6例早期浸润性鳞状细胞癌中的5例以及37例浅表性基底细胞癌中的36例在单次治疗后完全缓解。10例结节溃疡性基底细胞癌中只有1例完全消退。8例恶性黑色素瘤皮肤转移治疗失败。
内源性卟啉光动力疗法对浅表上皮性皮肤肿瘤有效。
