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[阻塞性睡眠呼吸暂停和打鼾患者清醒时间的变化——一项初步研究的结果]

[Changes in the time spent awake in obstructive sleep apnea and snoring--results of a pilot study].

作者信息

Wenzel G, Schönhofer B, Wenzel M, Köhler D

机构信息

Krankenhaus Kloster Grafschaft, Zentrum für Pneumologie, Beatmungs- und Schlafmedizin, Schmallenberg.

出版信息

Pneumologie. 1997 Dec;51(12):1111-4.

PMID:9487772
Abstract

Continuous positive airway pressure (CPAP) therapy reduces sleeping time per day and daytime sleepiness in obstructive sleep apnoea (OSA) and heavy snoring. Due to sleep fragmentation the OSA and heavy snoring are associated with a daytime sleepiness and increased necessity of sleep. In this pilot study the effect of CPAP-therapy on daytime sleepiness and sleep time during 24 hours were assessed in patients with OSA or heavy snoring (daytime sleepiness, none or slight apnoea with AHI < 10/h and benefit of CPAP). We studies 42 patients with OSA (AHI: 34.5 +/- 23.6) and 15 patients with heavy snoring: inclusion criteria: Patients with OSA (AHI > 10/h, ESS-Score > 8) and heavy snoring (AHI < 10/h, ESS-Score > 8) who were treated with nCPAP. Before and 2 months after initiation the CPAP-therapy all patients completed diary cards recording the sleeping time/day for 1 month; additionally they scored sleepiness using the Epworth sleepiness scale (ESS-score ranged from 0 to 24, the higher the score the worse the sleepiness) before and 2 months after initiation the CPAP-therapy. In the whole study population nCPAP-therapy reduced the sleeping time significantly by a mean period of 46 minutes per 24 hours (from 8.3 +/- 1.3 to 7.5 +/- 1.2 hours, p < 0.001) and improved the ESS score from 13.7 +/- 4.6 to 6.1 +/- 3.6 (p < 0.0001). In respect of the change of sleeping time/day and of the sleepiness score there was no significant difference between the OSA and heavy snoring group. With CPAP the AHI in OSA patients was reduced from 34.5 +/- 23.6/h to 3.2 +/- 3.2/h. Due to the improvement of sleep-related breathing disorders CPAP therapy reduced the mean sleeping time/day by approximately 10% and the daytime sleepiness score both in patients with OSA and heavy snoring compared to the pretreatment period.

摘要

持续气道正压通气(CPAP)治疗可减少阻塞性睡眠呼吸暂停(OSA)和重度打鼾患者的每日睡眠时间及日间嗜睡情况。由于睡眠碎片化,OSA和重度打鼾与日间嗜睡及睡眠需求增加有关。在这项初步研究中,对OSA或重度打鼾患者(日间嗜睡,无或轻度呼吸暂停且呼吸暂停低通气指数[AHI]<10次/小时且CPAP治疗有益)进行了CPAP治疗对日间嗜睡和24小时睡眠时间影响的评估。我们研究了42例OSA患者(AHI:34.5±23.6)和15例重度打鼾患者:纳入标准:接受无创CPAP治疗的OSA患者(AHI>10次/小时,Epworth嗜睡量表[ESS]评分>8)和重度打鼾患者(AHI<10次/小时,ESS评分>8)。在开始CPAP治疗前及治疗2个月后,所有患者完成记录1个月每日睡眠时间的日记卡;此外,他们在开始CPAP治疗前及治疗2个月后使用Epworth嗜睡量表对嗜睡程度进行评分(ESS评分范围为0至24,分数越高嗜睡越严重)。在整个研究人群中,无创CPAP治疗使每日睡眠时间显著减少,平均每24小时减少46分钟(从8.3±1.3小时降至7.5±1.2小时,p<0.001),ESS评分从13.7±4.6提高至6.1±3.6(p<0.0001)。在每日睡眠时间变化和嗜睡评分方面,OSA组和重度打鼾组之间无显著差异。使用CPAP后,OSA患者的AHI从34.5±23.6次/小时降至3.2±3.2次/小时。由于睡眠相关呼吸障碍得到改善,与治疗前相比,CPAP治疗使OSA和重度打鼾患者的平均每日睡眠时间减少约10%,日间嗜睡评分也降低。

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