Graczyk T K, Cranfield M R, Dunning C, Strandberg J D
Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.
J Parasitol. 1998 Feb;84(1):178-80.
Fatal intestinal cryptosporidiosis of unknown source and unexplained epizootiology is reported in a neonatal captive African hedgehog (Ateletrinx albiventris) and for the first time in a hedgehog species. The infection, confined to ileum, jejunum, and colon, was extremely severe in the lower jejunum where over 75% of the epithelial cells harbored the pathogen. The ileum and the jejunum displayed moderate and severe villus atrophy and mucosal hyperplasia. Lamina propria and mucosa were infiltrated by eosinophils, lymphocytes, and macrophages. Developmental stages of Cryptosporidium sp. produced a positive reaction with immunofluorescent antibody for detection of the human pathogen, Cryptosporidium parvum. Personnel of captive centers with hedgehogs should be alerted and undertake appropriate precautions to prevent zoonotic transmission. Commercially offered hedgehog-pets may pose a risk for Cryptosporidium infection for human immunodeficiency virus-infected people.
据报道，一只圈养的新生非洲刺猬（Ateletrinx albiventris）感染了来源不明且流行病学原因不明的致命肠道隐孢子虫病，这在刺猬物种中尚属首次。感染局限于回肠、空肠和结肠，在空肠下段极为严重，超过75%的上皮细胞携带病原体。回肠和空肠显示出中度和重度绒毛萎缩以及黏膜增生。固有层和黏膜有嗜酸性粒细胞、淋巴细胞和巨噬细胞浸润。隐孢子虫属的发育阶段与用于检测人类病原体微小隐孢子虫的免疫荧光抗体产生阳性反应。刺猬圈养中心的工作人员应提高警惕并采取适当预防措施，以防止人畜共患病传播。商业出售的刺猬宠物可能会对感染人类免疫缺陷病毒的人构成隐孢子虫感染风险。
