Senf L
Folia Haematol Int Mag Klin Morphol Blutforsch. 1979;106(5-6):899-907.
A method of measuring the distribution kinetics of radioactive 51Cr-EDTA between human plasma and a fibrinoclot are represented. In the presence of streptokinase the speed of distribution is a measure for the progressing of fibrinolysis. The results of measurement as well as the model calculations on the kinetics of fibrinolysis by streptokinase with physiologically relevant data are compared with those observations on the mechanism of thrombolysis obtained from biochemical findings. These results indicate that at the dissolution speeds of the clots observed clinically or experimentally the diffusion of streptokinase activator complexes into the clot seems to play no important role.
本文介绍了一种测量放射性51Cr-EDTA在人血浆和纤维蛋白凝块之间分布动力学的方法。在链激酶存在的情况下，分布速度是纤维蛋白溶解进程的一种度量。将测量结果以及基于生理相关数据对链激酶纤维蛋白溶解动力学的模型计算结果，与从生化研究结果中获得的关于溶栓机制的观察结果进行了比较。这些结果表明，在临床或实验观察到的凝块溶解速度下，链激酶激活剂复合物向凝块中的扩散似乎不起重要作用。
