Luyasu V, Bauraind O, Bernard P, Bietlot Y, Brasseur C, Englebert J, Fiasse L, Givron O, Longueville E, Melard J L, Michel M, Wacquez M
Service de Biologie Clinique, Clinique Saint-Pierre, Ottignies.
Acta Clin Belg. 1997;52(6):381-7. doi: 10.1080/17843286.1997.11718604.
We report seven cases of subclinical congenital toxoplasmosis secondary to maternal primary infections. Mothers were infected between two and four weeks prior to delivery. The diagnostic criteria of congenital infections included: IgM antibody (Ab) (1 case); IgM and IgA Ab (1 case); a real IgG seroconversion in the neonatal and postnatal samples (3 cases); persistence of IgG Ab beyond 6 months post-delivery (2 cases). A treatment was initiated, including a combination of pyrimethamine + sulfadiazine (6 cases); trimethoprim + sulfamethoxazole (1 case). This retrospective study suggests that it is important to screen the non-immune pregnant women until delivery. We confirmed the usefulness of a combination of isotypes of antibodies for the accurate assessment of congenital infection. Finally, infected infants have to be treated and monitored clinically and immunologically during the first year of life.
