Samuelsson R G, Nagy G
Acta Physiol Scand. 1976 Jun;97(2):158-65. doi: 10.1111/j.1748-1716.1976.tb10248.x.
In anesthetized dogs electrocardiogram and monophasic action potentials (MAPs) were recorded from the right atrium and the right ventricle by intracardiac suction electrode technique. The animals were subjected, by means of ventilation with CO2 and hyperventilation, to periods of respiratory acidosis and respiratory alkalosis, respectively. Pronounced respiratory acidosis induced an increased sympathetic activity followed by a decrease in heart rate and prolongation of the A-V conduction time whereas the shape and duration of the atrial and ventricular MAPs remained unaltered. Arterial hypoxia in combination with pronounced respiratory acidosis did not influence the MAP durations. Respiratory alkalosis resulted in an increased sympathetic influence on the heart activity whereas the shape and duration of the atrial and the ventricular MAPs remained unaffected. During pronounced hyperventilation with increasing central venous pressure an increased parasympathetic influence on the heart activity with decrease in the heart rate, prolongation of the A-V conduction time and shortening of the atrial MAP duration was recorded.
在麻醉犬身上，采用心内吸引电极技术记录右心房和右心室的心电图及单相动作电位（MAPs）。通过二氧化碳通气和过度通气，分别使动物处于呼吸性酸中毒和呼吸性碱中毒状态。明显的呼吸性酸中毒导致交感神经活动增强，随后心率降低和房室传导时间延长，而心房和心室MAPs的形态和持续时间保持不变。动脉缺氧与明显的呼吸性酸中毒相结合并未影响MAPs的持续时间。呼吸性碱中毒导致交感神经对心脏活动的影响增强，而心房和心室MAPs的形态和持续时间未受影响。在明显过度通气且中心静脉压升高时，记录到副交感神经对心脏活动的影响增强，心率降低，房室传导时间延长，心房MAP持续时间缩短。
