Iskakov A A, L'vov K M
Akmolinsk State Medical Institute, Ministry of Health, Kazakhstan.
Biofizika. 1997 Nov-Dec;42(6):1192-6.
The kinetic study of decay reaction of macroradicals in proteins with the use of a stochastic dynamic model of proteins has been carried out. Two types of distributions of the effective coefficients (diffusion, friction and viscosity) corresponding to two types of conformational motion of proteins have been obtained. The distributions of the effective parameters corresponding to the diffusion of protein molecule over conformational states are equal for all. The distributions of the same parameters corresponding to the diffusion of individual atomic groups in protein molecule are different and influenced by proteins, temperature and humidity. In dry proteins macroradicals disappear at the more conformational mobility only as compared with proteins in water.
利用蛋白质的随机动力学模型对蛋白质中大分子自由基的衰变反应进行了动力学研究。获得了与蛋白质两种构象运动相对应的两种有效系数（扩散、摩擦和粘度）分布。所有蛋白质分子在构象状态上扩散对应的有效参数分布是相等的。蛋白质分子中单个原子基团扩散对应的相同参数分布不同，且受蛋白质、温度和湿度影响。与水中的蛋白质相比，干燥蛋白质中的大分子自由基仅在构象流动性更大时消失。
