血红蛋白Q印度型，α64（E13）位天冬氨酸被组氨酸取代，以及一个加拿大家庭中的β地中海贫血。
Hemoglobin QIndia, alpha 64 (E13) Asp replaced by His, and beta-thalassemia in a Canadian family.
作者信息
Schmidt R M, Bechtel K C, Moo-Penn W F
出版信息
Am J Clin Pathol. 1976 Aug;66(2):446-8. doi: 10.1093/ajcp/66.2.446.
PMID:949043
Abstract
Cellulose acetate electrophoresis at pH 8.4 showed a hemoglobin variant with the mobility of hemoglobin S in a Canadian family. Sequence analysis revealed that histidine was substituted for aspartic acid at position 64 in the alpha-chain. This variant was found in association with a beta-thalassemia trait condition.
摘要
在pH 8.4条件下进行的醋酸纤维素电泳显示，一个加拿大家庭中存在一种血红蛋白变体，其迁移率与血红蛋白S相同。序列分析表明，α链第64位的天冬氨酸被组氨酸取代。该变体与β地中海贫血性状相关。
Zotero 插件