[儿茶酚胺对大鼠多形核白细胞鲁米诺依赖性化学发光的影响]
[The effect of catecholamines on the luminol-dependent chemiluminescence of rat polymorphonuclear leukocytes].
作者信息
Potselueva M M, Marinov B S, Pustovidko A V, Kudzina L Iu, Evtodienko Iu V
机构信息
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino.
出版信息
Tsitologiia. 1997;39(8):699-704.
The effects of catecholamines on reactive oxygen species (ROS) generation by polymorphonuclear leucocytes were studied using chemiluminescence (CL). It has been found that catecholamines in 10(-9)-10(-10) M concentration range are able to increase reactive oxygen species generation. Within the micromolar concentration range (10(-6)-10(-5) M) cetacholamines (CA) strongly suppress CL intensity and ROS production. The efficiency of inhibitory action of CA: noradrenaline > adrenaline > dopamine > L-DOPA correspond to their redox properties. A conclusion is made that peroxidase is one of the main targets of CA effect.
利用化学发光法（CL）研究了儿茶酚胺对多形核白细胞产生活性氧（ROS）的影响。已发现浓度在10⁻⁹ - 10⁻¹⁰ M范围内的儿茶酚胺能够增加活性氧的产生。在微摩尔浓度范围（10⁻⁶ - 10⁻⁵ M）内，儿茶酚胺（CA）强烈抑制化学发光强度和活性氧的产生。CA的抑制作用效率：去甲肾上腺素＞肾上腺素＞多巴胺＞左旋多巴，与其氧化还原特性相对应。得出的结论是，过氧化物酶是CA作用的主要靶点之一。
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