[The effect of catecholamines on the luminol-dependent chemiluminescence of rat polymorphonuclear leukocytes].

The effects of catecholamines on reactive oxygen species (ROS) generation by polymorphonuclear leucocytes were studied using chemiluminescence (CL). It has been found that catecholamines in 10(-9)-10(-10) M concentration range are able to increase reactive oxygen species generation. Within the micromolar concentration range (10(-6)-10(-5) M) cetacholamines (CA) strongly suppress CL intensity and ROS production. The efficiency of inhibitory action of CA: noradrenaline > adrenaline > dopamine > L-DOPA correspond to their redox properties. A conclusion is made that peroxidase is one of the main targets of CA effect.