干扰素在小鼠中通过细菌核糖体以及肺炎克雷伯菌膜糖蛋白作为佐剂抵抗甲型流感病毒的作用。
Role of interferon in mice in protection against influenza A virus by bacterial ribosomes together with membranal glycoproteins of Klebsiella pneumoniae as adjuvant.
作者信息
Robert D, Quillon J P, Ivanoff B, Beaudry Y, Fontanges R, Normier G, Pinel A M, D'hinterland L D
出版信息
Infect Immun. 1979 Nov;26(2):515-9. doi: 10.1128/iai.26.2.515-519.1979.
Nonspecific protection against infectious aerosols of influenza A virus was obtained in Swiss mice after vaccination by aerosols of bacterial ribosomes together with membranal glycoproteins extracted from Klebsiella pneumoniae as the adjuvant. It was shown that repeated stimulant aerosols were necessary to obtain this protection. Routine estimation of serum interferon levels after administration of the association of ribosomes plus membranal glycoproteins to the animals by aerosol or intravenous route showed that there was no correlation between protection and the presence of serum interferon. It was shown that the serum interferon-inducer activity was due to ribosomes. No induction of serum interferon was obtained with membranal glycoproteins used separately. Local liberation of interferon in the mucous membrane of the upper respiratory tract was not investigated.
在瑞士小鼠中，通过气溶胶接种细菌核糖体以及从肺炎克雷伯菌中提取的膜糖蛋白作为佐剂，可获得针对甲型流感病毒感染性气溶胶的非特异性保护。结果表明，需要反复进行刺激气溶胶接种才能获得这种保护。通过气溶胶或静脉途径给动物施用核糖体加膜糖蛋白组合后，对血清干扰素水平进行常规评估发现，保护作用与血清干扰素的存在之间没有相关性。结果表明，血清干扰素诱导活性归因于核糖体。单独使用膜糖蛋白未诱导出血清干扰素。未对上呼吸道黏膜中干扰素的局部释放进行研究。
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