头孢曲嗪（SK&F 60771），一种新型口服头孢菌素：口服或肌内注射后人体的血清水平及尿中回收率——与头孢氨苄和头孢唑林的对比研究
Cefatrizine (SK&F 60771), a new oral cephalosporin: serum levels and urinary recovery in humans after oral or intramuscular administration--comparative study with cephalexin and cefazolin.
作者信息
Actor P, Pitkin D H, Lucyszyn G, Weisbach J A, Bran J L
出版信息
Antimicrob Agents Chemother. 1976 May;9(5):800-3. doi: 10.1128/AAC.9.5.800.
Cefatrizine (SK&F 60771), a new broad-spectrum cephalosporin, was administered in a 0.5-g dose either orally or intramuscularly to volunteers in a crossover study. After oral administration, the average peak serum levels were 5.6 and 22.1 mug/ml for cefatrizine and cephalexin, respectively. The serum half-life of cefatrizine appeared to be more extended than that of cephalexin. Urinary recovery of cefatrizine (35%) was approximately half that of cephalexin (68%) after oral administration. After intramuscular injection of 0.5 g, the average peak serum level of cefatrizine (12.0 mug/ml) was approximately one-fourth that of cefazolin (44.0 mug/ml). The serum half-life after intramuscular injection was 86 min for cefatrizine and 118 min for cefazolin. Urinary recovery was 45% of the intramuscularly administered dose, as compared with cefazolin, which was 74%.
头孢曲嗪（SK&F 60771）是一种新型广谱头孢菌素，在一项交叉研究中，以0.5克的剂量口服或肌内注射给志愿者。口服给药后，头孢曲嗪和头孢氨苄的平均血清峰值水平分别为5.6微克/毫升和22.1微克/毫升。头孢曲嗪的血清半衰期似乎比头孢氨苄更长。口服给药后，头孢曲嗪的尿回收率（35%）约为头孢氨苄（68%）的一半。肌内注射0.5克后，头孢曲嗪的平均血清峰值水平（12.0微克/毫升）约为头孢唑林（44.0微克/毫升）的四分之一。头孢曲嗪肌内注射后的血清半衰期为86分钟，头孢唑林为118分钟。尿回收率为肌内给药剂量的45%，而头孢唑林为74%。
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