Weinstein A J
Drugs. 1980 Aug;20(2):137-54. doi: 10.2165/00003495-198020020-00007.
The cephalosporin antibiotics have been employed with increasing frequency since their introduction into clinical practice in the early 1960s. With the exception of cephaloridine, cephalosporin compounds are not associated with the production of significant untoward effects. The availability of newer cephalosporins, both oral and parenteral, with enhanced antibacterial activity, has expanded the clinical indications for administration of these antibiotics.
自20世纪60年代初引入临床实践以来，头孢菌素类抗生素的使用频率不断增加。除头孢噻啶外，头孢菌素类化合物一般不会产生明显的不良反应。新型口服和注射用头孢菌素的出现，增强了抗菌活性，扩大了这些抗生素的临床应用指征。
