硫酸葡聚糖纤维素低密度脂蛋白去除术可降低血清淀粉样蛋白A和P蛋白水平。

Serum amyloid A and P protein levels are lowered by dextran sulfate cellulose low-density lipoprotein apheresis.

作者信息

Yoshidome H, Kuriyama M, Fujiyama J, Osame M

机构信息

The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka, Japan.

出版信息

Artif Organs. 1998 Feb;22(2):144-8. doi: 10.1046/j.1525-1594.1998.05065.x.

DOI:10.1046/j.1525-1594.1998.05065.x

PMID:9491906

Abstract

The present study describes the short-term effect of dextran sulfate cellulose (DSC) low-density lipoprotein (LDL) apheresis using a plasma separator equipped with a polysulfone (PS) membrane filter (PS/DSC-LDL apheresis) on the serum amyloid A (SAA) and P (SAP) protein levels during treatment in a patient with familial hypercholesterolemia (type IIa, heterozygote). PS/DSC-LDL apheresis markedly lowered both the SAA (reduction percentage, 84.1+/-8.2%) and SAP (91.4+/-5%) levels, which returned to their respective initial levels within 4 days. Experimentally, the levels of both proteins also decreased on passage through the DSC minicolumn without a PS membrane, indicating that the DSC resin had an affinity to both proteins. These results suggest that PS/DSC-LDL apheresis may be advantageous for amyloid protein accumulating disorders, including amyloidosis and atherosclerosis.

摘要

本研究描述了使用配备聚砜（PS）膜过滤器的血浆分离器进行硫酸葡聚糖纤维素（DSC）低密度脂蛋白（LDL）单采术（PS/DSC-LDL单采术）对家族性高胆固醇血症（IIa型，杂合子）患者治疗期间血清淀粉样蛋白A（SAA）和P（SAP）蛋白水平的短期影响。PS/DSC-LDL单采术显著降低了SAA（降低百分比，84.1±8.2%）和SAP（91.4±5%）水平，且这些水平在4天内恢复到各自的初始水平。在实验中，两种蛋白的水平在通过没有PS膜的DSC微型柱时也降低了，这表明DSC树脂对这两种蛋白都有亲和力。这些结果表明，PS/DSC-LDL单采术可能对包括淀粉样变性和动脉粥样硬化在内的淀粉样蛋白蓄积性疾病有益。