急性病毒感染期间抗原特异性CD8 + T细胞的大量扩增。
Massive expansion of antigen-specific CD8+ T cells during an acute virus infection.
作者信息
Butz E A, Bevan M J
机构信息
Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle 98195, USA.
出版信息
Immunity. 1998 Feb;8(2):167-75. doi: 10.1016/s1074-7613(00)80469-0.
Abstract
During LCMV infection, CD8+ T cells expand greatly. Bystander activation has been thought to play a role because few cells score as LCMV specific in limiting dilution analysis. In contrast, we find that at least a quarter of the CD8+ cells secrete IFNgamma specifically in response to LCMV peptides at the peak of the response. Moreover, by analyzing the expansion of adoptively transferred LCMV-specific, TCR-transgenic CD8+ T cells in congenic hosts, we have determined that most of the CD8+ cell expansion is virus specific. Analysis of the effect of the monospecific TCR-transgenic T cells on the host response to three LCMV epitopes suggests that CTL precursors compete for sites on the APC in an epitope-specific fashion and that this competition determines the specificity of the response.
摘要
在淋巴细胞脉络丛脑膜炎病毒（LCMV）感染期间，CD8 + T细胞大量扩增。旁观者激活被认为发挥了作用，因为在有限稀释分析中，很少有细胞被判定为LCMV特异性细胞。相比之下，我们发现，在反应高峰期，至少四分之一的CD8 +细胞会特异性分泌γ干扰素以响应LCMV肽。此外，通过分析在同基因宿主中过继转移的LCMV特异性、TCR转基因CD8 + T细胞的扩增情况，我们确定大部分CD8 +细胞的扩增是病毒特异性的。对单特异性TCR转基因T细胞对宿主针对三种LCMV表位反应的影响分析表明，细胞毒性T淋巴细胞（CTL）前体以表位特异性方式竞争抗原呈递细胞（APC）上的位点，并且这种竞争决定了反应的特异性。
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