Hiatt R B, Goodman I
Arch Surg. 1976 Sep;111(9):997-9. doi: 10.1001/archsurg.1976.01360270069013.
Seventeen patients with symptoms of acute or chronic postgastrectomy obstruction of a life-threatening nature have been treated with a peptide substance that is isolated from the bovine neurohypophysis (coherin) and has a regularizing effect on the electromotor performance of the small intestine of the dog and man. All patients treated in this study were relieved of their obstructive symptoms. After weight gain began, the majority of patients with acute obstruction were able to discontinue coherin therapy. Five patients with chronic obstruction have required prolonged treatment with coherin to maintain normal alimentary function.
17例患有急性或慢性胃切除术后具有危及生命性质梗阻症状的患者，接受了一种从牛神经垂体分离出的肽物质（粘连蛋白）的治疗，该物质对狗和人的小肠电运动性能具有调节作用。本研究中接受治疗的所有患者梗阻症状均得到缓解。体重开始增加后，大多数急性梗阻患者能够停止粘连蛋白治疗。5例慢性梗阻患者需要长期使用粘连蛋白治疗以维持正常的消化功能。
