Reynoldson J A, Behnke J M, Pallant L J, Macnish M G, Gilbert F, Giles S, Spargo R J, Thompson R C
World Health Organization Collaborating Centre for the Molecular Epidemiology of Parasitic Infections, Murdoch University, Western Australia.
Acta Trop. 1997 Dec;68(3):301-12. doi: 10.1016/s0001-706x(97)00106-x.
A survey of 108 individuals from a coastal Aboriginal community in north Western Australia revealed that two species of gastrointestinal protozoan parasites (Giardia duodenalis--39.8%, Entamoeba coli--40.7%) and five gastrointestinal helminths (Hymenolepis nana--54.6%, Hookworm [Ancylostoma duodenale]--30.6%, Enterobius vermicularis--6.5%, Trichuris trichiura--2.8%, Strongyloides stercoralis 1.9%) were present. A total of 29 individuals infected with hookworm were offered treatment with either pyrantel pamoate at a single dose rate of 10 mg/kg body weight or albendazole (single 400 mg dose). Seven days after treatment stool samples were examined. Pyrantel had no significant effect against hookworm. In contrast, albendazole cleared hookworm infections completely and reduced the prevalence of Giardia. The former result suggests that locally A. duodenale is resistant to pyrantel and despite its relatively low cost and wide availability, should not be considered a drug of choice at this dose rate in the treatment of hookworm infections (A. duodenale) in endemic regions.
对西澳大利亚北部一个沿海原住民社区的108人进行的一项调查显示，存在两种胃肠道原生动物寄生虫（十二指肠贾第虫——39.8%，结肠内阿米巴——40.7%）和五种胃肠道蠕虫（微小膜壳绦虫——54.6%，钩虫[十二指肠钩口线虫]——30.6%，蠕形住肠线虫——6.5%，鞭虫——2.8%，粪类圆线虫——1.9%）。共有29名感染钩虫的个体接受了治疗，治疗药物为按10毫克/千克体重的单剂量率使用的噻嘧啶双羟萘酸盐或阿苯达唑（单次400毫克剂量）。治疗七天后检查粪便样本。噻嘧啶对钩虫没有显著效果。相比之下，阿苯达唑完全清除了钩虫感染并降低了贾第虫的患病率。前一个结果表明，当地的十二指肠钩口线虫对噻嘧啶有抗性，尽管其成本相对较低且广泛可得，但在流行地区以该剂量率治疗钩虫感染（十二指肠钩口线虫）时，不应将其视为首选药物。
