阿苯达唑和噻嘧啶治疗肠道蠕虫病及控制钩虫感染复发的效果
[Effect of albendazole and pyrantel in treating intestinal helminthiasis and controlling the recurrence of hookworm infections].
作者信息
Zhang X R, Yang W J, Yang C, Liao Z Y, Liu Y M, Tang Z J, Feng D G, Tao S X, Guo X Q, He S Q
机构信息
Institute of Antiparasitic Diseases, Sichuan Academy of Medical Sciences, Chengdu.
出版信息
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1990;8(2):96-9.
A total of 720 human intestinal helminthic infections were divided into 4 groups and treated with albendazole 400mg/d x 3d, 400mg/d x 5d, pyrantel 1,500mg/d x 3d, or 1,500mg/d x 5d. Half a month after treatment, the negative rates of hookworm egg were 98.6, 98.6, 86.2 and 93.5%, those of ascaris egg were 96.5, 98.2, 92.9 and 96.3%, and those of whipworm egg were 86.4, 89.0, 68.9 and 67.0% respectively. Reduction rate of hookworm egg reached more than 98% in all the 4 groups. Six months after treatment, however, the positive rates of all the 4 groups rose again in varying degrees. The predominant species of hookworm infections was Necator americanus before the treatment and Ancylostoma duodenale after the treatment. It was demonstrated that the recurrence of hookworm infection resulted from A. duodenale infections, while a single dose of 400mg albendazole per day for 3 or 5 days showed good effect in controlling the recurrence of hookworm infections in a certain area.
共720例人体肠道蠕虫感染患者被分为4组，分别接受阿苯达唑400mg/d×3天、400mg/d×5天、噻嘧啶1500mg/d×3天或1500mg/d×5天的治疗。治疗半个月后，钩虫卵阴转率分别为98.6%、98.6%、86.2%和93.5%，蛔虫卵阴转率分别为96.5%、98.2%、92.9%和96.3%，鞭虫卵阴转率分别为86.4%、89.0%、68.9%和67.0%。4组钩虫卵减少率均达98%以上。然而，治疗6个月后，4组的阳性率均不同程度再次上升。治疗前钩虫感染的优势虫种为美洲板口线虫，治疗后为十二指肠钩口线虫。结果表明，钩虫感染的复发是由十二指肠钩口线虫感染引起的，而每日单次服用400mg阿苯达唑3天或5天在一定区域对控制钩虫感染复发显示出良好效果。
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