Narfström K, Ekesten B
Department of Medicine and Surgery, Swedish University of Agricultural Sciences, Uppsala.
Am J Vet Res. 1998 Feb;59(2):221-6.
To evaluate the function of the outer retina in Papillons with and without hereditary retinal degeneration.
45 Papillons, median age 1.7 (range, 0.8 to 5.1) years.
Complete physical and ophthalmic examinations were done prior to performing electroretinography under general anesthesia. Full-field electroretinograms (ERG) were recorded, using a special-purpose computer system. Eleven specific ERG responses were recorded, graphed, and evaluated, using age-matched Papillons.
Severely decreased retinal function was detected in 8 Papillons. The youngest affected dog was 1.2 years old. In affected dogs, amplitudes of responses mainly originating from the rod system were severely decreased, compared with those originating from the cone system.
Papillons represent another breed of dog affected by a hereditary photoreceptor degeneration that can be detected at an early age by using ERG. A reliable age for diagnosis using ERG is considered to be 1.5 years.
Through and precise ERG procedures and protocols are needed to reliably obtain an early diagnosis of progressive retinal atrophy.
评估有无遗传性视网膜变性的蝴蝶犬的外层视网膜功能。
45只蝴蝶犬，中位年龄1.7（范围0.8至5.1）岁。
在全身麻醉下进行视网膜电图检查之前，先进行全面的体格和眼科检查。使用专用计算机系统记录全视野视网膜电图（ERG）。记录、绘制并评估11种特定的ERG反应，与年龄匹配的蝴蝶犬进行比较。
在8只蝴蝶犬中检测到视网膜功能严重下降。受影响最年轻的犬为1.2岁。与源于视锥系统的反应相比，受影响犬中主要源于视杆系统的反应幅度严重降低。
蝴蝶犬是另一种受遗传性光感受器变性影响的犬种，可通过ERG在早期检测到。使用ERG进行诊断的可靠年龄被认为是1.5岁。
需要通过精确的ERG程序和方案来可靠地早期诊断进行性视网膜萎缩。
