Van Erum R, Carels C, Verbeke G, de Zegher F
Department of Orthodontics, University of Leuven, Belgium.
J Craniofac Genet Dev Biol. 1997 Oct-Dec;17(4):184-9.
The craniofacial growth of 17 children born small for gestational age (SGA), who had received high-dose growth hormone (GH) treatment, was studied during the post-treatment phase. The preceding GH treatment consisted of a daily s.c. dose of either 0.2 or 0.3 IU/kg for 2 years. The group consisted of 9 girls and 8 boys with a mean (range) age of 6.9 yr (4-10 years) at the start of the post-treatment period, a mean (SD) bone age of 6.3 (2.1) years, and a mean (SD) height for chronological age of -1.0 (0.6) SDS. During the post-treatment period of 2 years, a catch-down effect was found for all linear craniofacial measurements in both treatment groups, even for the components that had not presented accelerated growth during GH treatment. Major growth vectors, such as the posterior total face height (S-Go) and the overall length of the mandible (Art-Pog), showed a low growth velocity, while minor growth parameters remained almost unchanged during this period. The angular measurements showed no significant changes during this period. It can be concluded that craniofacial growth in short SGA children showed, after a period of GH-induced acceleration, a catch-down period when GH administration is stopped. Despite this low post-treatment growth velocity, the craniofacial linear measurements in lateral aspect, remained larger than in untreated children.
对17名出生时小于胎龄（SGA）且接受过高剂量生长激素（GH）治疗的儿童在治疗后阶段的颅面生长情况进行了研究。之前的GH治疗为每日皮下注射剂量0.2或0.3 IU/kg，持续2年。该组包括9名女孩和8名男孩，治疗后阶段开始时的平均（范围）年龄为6.9岁（4 - 10岁），平均（标准差）骨龄为6.3（2.1）岁，按实足年龄计算的平均（标准差）身高为 -1.0（0.6）标准差。在2年的治疗后阶段，两个治疗组的所有颅面线性测量值均出现追赶下降效应，即使是在GH治疗期间未出现加速生长的部分。主要生长向量，如全脸后段高度（S - Go）和下颌骨全长（Art - Pog），生长速度较低，而在此期间次要生长参数几乎保持不变。在此期间角度测量值无显著变化。可以得出结论，身材矮小的SGA儿童在经历一段GH诱导的加速生长后，在停止使用GH时会出现追赶下降期。尽管治疗后的生长速度较低，但侧面的颅面线性测量值仍大于未治疗的儿童。
