造血期兔胎儿肝脏中二氢叶酸还原酶和胸苷酸合成酶的活性。
Dihydrofolate reductase and thymidylate synthetase activities in the liver of rabbit foetuses during the haemapoietic period.
作者信息
Bourbon J R
出版信息
Biochem J. 1976 Jun 1;155(3):713-5. doi: 10.1042/bj1550713.
Abstract
Dihydrofolate reductase activity did not change with variations of mitotic rate in foetal rabbit haemopoietic tissue, whereas the activity of thymidylate synthetase declined with decrease in cell divisions. Both the activities were normal in the brachydactylia strain, in which a failure in folate metabolism was previously assumed.
摘要
在胎兔造血组织中，二氢叶酸还原酶的活性不会随着有丝分裂率的变化而改变，而胸苷酸合成酶的活性则随着细胞分裂的减少而下降。在短指畸形品系中，这两种酶的活性均正常，此前曾认为该品系存在叶酸代谢缺陷。
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本文引用的文献
1
HEPATIC HEMATOCYTOPOIESIS IN THE FETAL RABBIT: A LIGHT AND ELECTRON MICROSCOPIC STUDY.胎兔肝脏造血：光镜与电镜研究
Ann N Y Acad Sci. 1963 Dec 30;111:45-69. doi: 10.1111/j.1749-6632.1963.tb36948.x.
2
3
Dihydrofolate reductase from mouse liver and spleen. Purification, properties and inhibition by substituted 2,4-diaminopyrimidines and 4,6-diaminotriazines.来自小鼠肝脏和脾脏的二氢叶酸还原酶。纯化、性质以及被取代的2,4-二氨基嘧啶和4,6-二氨基三嗪抑制的情况
Biochem Pharmacol. 1971 Mar;20(3):561-74. doi: 10.1016/0006-2952(71)90143-2.
4
Activity of some enzymes of nucleic acid metabolism in developing rat liver.发育中大鼠肝脏核酸代谢相关某些酶的活性
Naunyn Schmiedebergs Arch Pharmacol. 1972;274(4):385-93. doi: 10.1007/BF00501275.
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Rat folic acid reductase activity during the perinatal period, in newborns, and after trimethoprim administration.围产期、新生儿期及给予甲氧苄啶后大鼠叶酸还原酶活性
Naunyn Schmiedebergs Arch Pharmacol. 1972;274(3):229-37. doi: 10.1007/BF00501932.
6
Synthesis of macromolecules during induction of haemoglobin synthesis by erythropoietin.促红细胞生成素诱导血红蛋白合成过程中大分子的合成
J Mol Biol. 1969 May 28;42(1):31-41. doi: 10.1016/0022-2836(69)90484-7.
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[Primordial red cells and congenital amputation in rabbit fetuses bearing the br gene].[携带br基因的兔胎儿中的原始红细胞与先天性截肢]
C R Acad Hebd Seances Acad Sci D. 1973 Sep 3;277(9):801-3.
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In vitro production of erythropoietin by mouse fetal liver.小鼠胎儿肝脏体外产生促红细胞生成素。
Blood. 1975 Jul;46(1):85-90.
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