Yamamoto C, Yoneda T, Yoshikawa M, Fu A, Takenaka I, Kobayashi A, Okamura I, Okamoto Y, Tsukaguchi K, Narita N
Second Department of Internal Medicine, Nara Medical University, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Nov;35(11):1191-5.
To investigate the relationship between malnutrition and TNF-alpha levels in patients with chronic obstructive pulmonary disease (COPD), we measured concentrations of TNF-alpha in serum from fifty four patients with stable COPD. The patients were divided into three groups, according to ideal body weight (IBW): group A, %IBW > or = 90; group B, 90 > %IBW > or = 80; group C, %IBW < 80. Serum TNF-alpha levels in group C were significantly higher than in group A (mean +/- SD; 3.00 +/- 0.43 pg/ml and 2.25 +/- 0.29 pg/ml, respectively, p < 0.0001), group B (2.41 +/- 0.47 pg/ml, p < 0.001), and healthy controls (2.33 +/- 0.30 pg/ml, p < 0.001) who were age- and %IBW-matched with patients in group C. Sixteen patients with COPD underwent body composition analysis by dual energy X-ray absorptiometry. Serum TNF-alpha levels in patients with COPD significantly correlated with fat mass (r = -0.67, p < 0.001). No association was observed between lean mass and serum TNF-alpha levels. These data suggest that TNF-alpha is involved with malnutrition in patients with COPD, and that TNF-alpha may cause a decrease in fat mass in patients with COPD.
为了研究慢性阻塞性肺疾病（COPD）患者营养不良与肿瘤坏死因子-α（TNF-α）水平之间的关系，我们检测了54例稳定期COPD患者血清中TNF-α的浓度。根据理想体重（IBW）将患者分为三组：A组，%IBW≥90；B组，90＞%IBW≥80；C组，%IBW＜80。C组血清TNF-α水平显著高于A组（均值±标准差；分别为3.00±0.43 pg/ml和2.25±0.29 pg/ml，p＜0.0001）、B组（2.41±0.47 pg/ml，p＜0.001）以及与C组患者年龄和%IBW匹配的健康对照组（2.33±0.30 pg/ml，p＜0.001）。16例COPD患者通过双能X线吸收法进行了身体成分分析。COPD患者血清TNF-α水平与脂肪量显著相关（r = -0.67，p＜0.001）。未观察到瘦体重与血清TNF-α水平之间存在关联。这些数据表明，TNF-α与COPD患者的营养不良有关，并且TNF-α可能导致COPD患者脂肪量减少。
