Naya Y, Ohe M, Fujino M, Akiyama Y, Kirisawa T, Kawakami Y
Department of Internal Medicine, Hokkaido Central Hospital for Social Health Insurance, Sapporo, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Nov;35(11):1245-51.
A 60-year-old woman was admitted for evaluation of an abnormal shadow in her chest X-ray. A chest roentgenogram revealed middle lobe atelectasis and a tomogram showed masses mainly in the right intermediate bronchus. In bronchoscopy, the bronchus was severely narrowed by irregularly surfaced masses. Microscopic examinations of transbronchial biopsy specimen showed the mucosal and submucosal tissue diffusedly infiltrated mainly by lymphocytes composed of small lymphocytes, centrocyte-like cells and monocytoid cells. The B-cell origin was suggested by a positive L-26 stain. Monoclonality of lymphocytes was proven by Southern blot analysis and in situ hybridization. The diagnosis was primary endobronchial lymphoma of mucosa-associated lymphoid tissue. The case was treated with chemotherapy protocol (CAMBO-VIP) and has been in complete remission for 20 months.
一名60岁女性因胸部X光片出现异常阴影而入院接受评估。胸部X线片显示中叶肺不张，断层扫描显示肿块主要位于右中间支气管。在支气管镜检查中，支气管被表面不规则的肿块严重狭窄。经支气管活检标本的显微镜检查显示，黏膜和黏膜下组织主要被由小淋巴细胞、中心细胞样细胞和单核样细胞组成的淋巴细胞弥漫浸润。L-26染色阳性提示B细胞起源。通过Southern印迹分析和原位杂交证实淋巴细胞的单克隆性。诊断为黏膜相关淋巴组织原发性支气管内淋巴瘤。该病例采用化疗方案（CAMBO-VIP）治疗，已完全缓解20个月。
