Klemfuss H, Southerland S, Britton K T
Department of Psychiatry, Veterans Affairs Medical Center, CA, USA.
Peptides. 1998;19(1):85-92. doi: 10.1016/s0196-9781(97)00266-0.
The role of central neuropeptide Y (NPY) in the cardiovascular response to social stress was evaluated in freely moving rats using telemetry. In unstressed rats, intracerebroventricular (ICV) administration of NPY and the selective Y1 receptor agonist [Leu31, Pro34]-NPY decreased blood pressure and heart rate, while the selective Y2 agonist NPY13-36 transiently raised blood pressure. NPY and [Leu31, Pro34]-NPY blunted elevations in blood pressure and pulse rate following exposure to the resident-intruder procedure, an established social stress paradigm. In contrast, the Y2 agonist significantly augmented stress-induced pressor effects. These observations indicate that the hypotensive effects of ICV NPY appear to be mediated by the Y1 receptor subtype and the NPY receptor subtypes may mediate opposing cardiovascular actions in response to stressful stimuli.
利用遥测技术，在自由活动的大鼠中评估了中枢神经肽Y（NPY）在对社会应激的心血管反应中的作用。在未受应激的大鼠中，脑室内（ICV）注射NPY和选择性Y1受体激动剂[Leu31, Pro34]-NPY可降低血压和心率，而选择性Y2激动剂NPY13-36可使血压短暂升高。NPY和[Leu31, Pro34]-NPY可减弱暴露于定居者-入侵者程序（一种既定的社会应激范式）后血压和脉搏率的升高。相比之下，Y2激动剂显著增强了应激诱导的升压作用。这些观察结果表明，ICV NPY的降压作用似乎由Y1受体亚型介导，并且NPY受体亚型可能介导对应激刺激的相反心血管作用。
