Kohler C, Gur R C, Swanson C L, Petty R, Gur R E
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104-4283, USA.
Biol Psychiatry. 1998 Feb 1;43(3):165-72. doi: 10.1016/S0006-3223(97)00033-4.
The presence of depression in schizophrenia has been well described with regard to stage and symptoms of illness; however, little is known about the possible etiology.
In an effort to advance the understanding of the neurobiology of depression in schizophrenia, we grouped patients with schizophrenia based on their ratings on the 21-item Hamilton Depression Rating Scale. There were 63 patients (35 men, 28 women) in the high (> or = 18) depression group and 81 patients (52 men, 29 women) in the low (< 18) depression group. The groups were compared in demographic, clinical, and eight neuropsychological domains.
The two groups differed in age at onset of illness, severity of delusions, and performance in a single neuropsychological domain: attention. The specific component of impaired attention was vigilance, with poorest performance seen in women with higher depression scores.
The presence of specific attentional impairment associated with depressive symptoms in schizophrenia is consistent with the hypothesis of frontal lobe dysfunction in depression, because these regions have been implicated in attentional processes.
精神分裂症中抑郁的存在已根据疾病阶段和症状得到充分描述；然而，对于其可能的病因知之甚少。
为了增进对精神分裂症中抑郁神经生物学的理解，我们根据患者在21项汉密尔顿抑郁量表上的评分对精神分裂症患者进行分组。高抑郁组（≥18分）有63例患者（35名男性，28名女性），低抑郁组（<18分）有81例患者（52名男性，29名女性）。对两组在人口统计学、临床和八个神经心理学领域进行比较。
两组在发病年龄、妄想严重程度以及单个神经心理学领域（注意力）的表现上存在差异。注意力受损的具体成分是警觉性，抑郁评分较高的女性表现最差。
精神分裂症中与抑郁症状相关的特定注意力损害的存在与抑郁症额叶功能障碍的假设一致，因为这些区域与注意力过程有关。
