Williams K P, Wilson S
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.
J Perinat Med. 1997;25(6):498-501. doi: 10.1515/jpme.1997.25.6.498.
To determine whether there is a difference among various ethnic groups in the complication of HELLP syndrome in a hypertensive pregnant population. A cohort of 498 pregnant women were entered into the study and multiple clinical parameters including blood pressure, birthweight percentile, gestational age were abstracted. HELLP syndrome was diagnosed in patients based on thrombocytopenia elevated liver enzymes and hemolysis. Maternal and fetal characteristics including the incidence of HELLP syndrome were compared among various ethnic groups and between the hypertensive categories using analysis of variance. The risk of developing HELLP syndrome was significantly higher in the White and Chinese population compared to the East Indian population (relative risk of 2.2). The development of HELLP syndrome was associated with an increased risk of the development of small for gestational age infants (SGA). The clinical correlates of the HELLP syndrome include ethnic group being highest in Chinese and White populations. A significant risk for the development of small for gestational age infants (SGA) exists in the presence of the HELLP syndrome.
为了确定高血压孕妇人群中，不同种族群体发生HELLP综合征并发症是否存在差异。498名孕妇纳入该研究，并提取了包括血压、出生体重百分位数、孕周在内的多个临床参数。根据血小板减少、肝酶升高和溶血情况对患者进行HELLP综合征诊断。使用方差分析比较不同种族群体以及高血压类别之间的母婴特征，包括HELLP综合征的发生率。与东印度人群相比，白人和中国人群发生HELLP综合征的风险显著更高（相对风险为2.2）。HELLP综合征的发生与小于胎龄儿（SGA）发生风险增加有关。HELLP综合征的临床相关因素包括种族群体，在中国和白人群体中最高。存在HELLP综合征时，发生小于胎龄儿（SGA）的风险显著增加。
