Jacob L S, Flaitz C M, Nichols C M, Hicks M J
University of Texas-Houston Health Science Center, Dental Branch, USA.
J Am Dent Assoc. 1998 Feb;129(2):187-94. doi: 10.14219/jada.archive.1998.0176.
The authors describe a clinicopathologic study that evaluated whether dentinal carious lesions are colonized by candidal organisms--and if so, whether there is a relationship between dentinal carious lesion colonization and clinical oral candidiasis, or OC, in HIV infection. Using light microscopy, the authors examined 30 extracted teeth with dentinal carious lesions from people in each of two groups: 30 consecutively treated HIV-positive patients and 30 consecutively treated HIV-negative patients. OC was diagnosed only in HIV-positive patients (40 percent). The dentinal carious lesion pattern in both groups was similar in occlusal, root and proximal caries. Candidal colonization of carious dentinal tubules was more frequent in HIV-positive subjects than it was in HIV-negative subjects. This research shows that it may be important to restore dentinal caries in HIV-infected patients to remove a protected niche for candidal organisms.
作者描述了一项临床病理研究，该研究评估牙本质龋损是否被念珠菌属微生物定植——如果是，那么在HIV感染中，牙本质龋损定植与临床口腔念珠菌病（OC）之间是否存在关联。作者使用光学显微镜检查了两组中每组30名患者的30颗有牙本质龋损的拔除牙齿：30名连续接受治疗的HIV阳性患者和30名连续接受治疗的HIV阴性患者。仅在HIV阳性患者中诊断出OC（40%）。两组的牙本质龋损模式在咬合面、牙根和邻面龋方面相似。HIV阳性受试者龋损牙本质小管的念珠菌定植比HIV阴性受试者更频繁。这项研究表明，对HIV感染患者的牙本质龋进行修复以消除念珠菌属微生物的受保护生态位可能很重要。
