Patriarca G, Schiavino D, Nucera E, Schinco G, Milani A, Gasbarrini G B
Department of Allergology and Internal Medicine, Universita Cattolica S. Cuore, Rome, Italy.
Hepatogastroenterology. 1998 Jan-Feb;45(19):52-8.
BACKGROUND/AIMS: Food allergy in children is still an unresolved problem that merits investigation, particularly when the food is fundamental for the child's growth. Reports in the literature that deal with the possibility of a desensitizing treatment are sporadic and often inconsistent, and no standardized protocols are yet available. In this paper we propose a standardized oral desensitization program for food allergy in children.
The treatment was carried out in 14 cases with allergy to food (milk in 6 cases, egg in 5, fish in 2 and apple in 1 case). The control group consisted of 10 age and sex matched allergic subjects (5 to milk, 4 to egg and 1 to fish), who underwent a strict elimination diet regimen.
Compliance to treatment was satisfactory, since 12 out of the 14 treated cases (85.7%) completed the program. Treatment was successful in 100% of the cases that completed the program: all the treated patients are now able to tolerate any food with no untoward effects or need for preventive drugs.
The proposed standardized oral desensitization treatment may represent a safe and convenient alternative in the management of food-allergic subjects.
背景/目的：儿童食物过敏仍是一个有待解决的问题，值得深入研究，尤其是当这种食物对儿童生长至关重要时。文献中关于脱敏治疗可能性的报道较为零散，且往往相互矛盾，目前尚无标准化方案。本文提出了一种针对儿童食物过敏的标准化口服脱敏方案。
对14例食物过敏患儿（牛奶过敏6例、鸡蛋过敏5例、鱼类过敏2例、苹果过敏1例）进行治疗。对照组由10名年龄和性别匹配的过敏受试者组成（牛奶过敏5例、鸡蛋过敏4例、鱼类过敏1例），他们接受严格的饮食回避方案。
治疗依从性良好，14例接受治疗的患儿中有12例（85.7%）完成了该方案。完成方案的病例治疗成功率为100%：所有接受治疗的患者现在都能够耐受任何食物，且无不良反应，也无需预防性用药。
所提出的标准化口服脱敏治疗可能是食物过敏患者管理中的一种安全、便捷的替代方法。
