Sirén J, Kärkkäinen P, Luukkonen P, Kiviluoto T, Kivilaakso E
Helsinki University Central Hospital, Department of Surgery.
Hepatogastroenterology. 1998 Jan-Feb;45(19):83-9.
Three cases of intrahepatic biliary cystadenoma with mesenchymal stroma and one case of biliary cystadenocarcinoma are presented. Their immunohistochemical features and the surgical treatment are discussed together with a brief review of the literature. The benign cystadenomas stained positive for cytokeratin and CA 19-9 in the epithelium of the cyst wall. Mesenchymal stromal cells were strongly positive for a-SMA and moderately positive for desmin. The epithelium of the cystadenocarcinoma, however, was positive only for cytokeratin and the stroma only for a-SMA. Our findings indicate that biliary cystadenomas seem to be of primitive hepatobiliary origin. Furthermore, the malignant variant cystadenocarcinoma may loose its immunoreactivity for CA 19-9 and desmin.
本文报告了3例伴有间充质基质的肝内胆管囊腺瘤及1例胆管囊腺癌。讨论了它们的免疫组化特征及手术治疗，并对相关文献进行了简要回顾。良性囊腺瘤在囊壁上皮中细胞角蛋白和CA 19-9染色呈阳性。间充质基质细胞α-平滑肌肌动蛋白（α-SMA）染色呈强阳性，结蛋白染色呈中度阳性。然而，囊腺癌的上皮仅细胞角蛋白染色呈阳性，基质仅α-SMA染色呈阳性。我们的研究结果表明，胆管囊腺瘤似乎起源于原始肝胆组织。此外，恶性变异型囊腺癌可能会失去其对CA 19-9和结蛋白的免疫反应性。
