Kedziora-Kornatowska K, Tkaczewski W, Blaszczyk J, Buczynski A, Chojnacki J, Kedziora J
Department of Gastroenterology, Military Medical University, Lodz, Poland.
Hepatogastroenterology. 1998 Jan-Feb;45(19):276-80.
BACKGROUND/AIMS: Our investigations was carried out in order to examine the effect of cimetidine, ranitidine and famotidine on the generation of free radicals, lipid peroxidation and enzymatic antioxidative defense in the blood of patients with peptic ulcer disease, clinically diagnosed as gastric or duodenal ulcer.
124 non-smoking males (aged 20-51 years), were randomly divided into 4 groups: 28 patients received intravenously 200 mg of cimetidine; 26 patients intravenously 50 mg comprised of ranitidine; 25 patients received intravenously 20 mg of famotidine; and 45 healthy men served as the control group. Superoxide dismutase activity, malonyldialdehyde concentration in blood platelets and superoxide anion generation in granulocytes were determined in all examined men. An assay of superoxide dismutase activity and malonyldialdehyde concentration were performed before drug administration and after 2 and 72 hours. Superoxide anion generation was estimated before drug administration and after 2 hours.
Our data indicate that all examined H2 receptor antagonists stimulate superoxide dismutase activity, but after 72 hours a distinct increase was observed, in addition to a decrease of malonyldialdehyde concentration. No differences have been observed in superoxide anion generation in patients with ulcer disease or in healthy subjects before and after ranitidine and famotidine administration. Only after 2 hours of cimetidine administration was a significant increase in superoxide anion generation observed.
We concluded that H2 receptor antagonists have a beneficial effect on antioxidative processes.
背景/目的：我们开展此项研究是为了检测西咪替丁、雷尼替丁和法莫替丁对消化性溃疡疾病患者（临床诊断为胃溃疡或十二指肠溃疡）血液中自由基生成、脂质过氧化及酶促抗氧化防御的影响。
124名不吸烟男性（年龄20 - 51岁）被随机分为4组：28名患者静脉注射200毫克西咪替丁；26名患者静脉注射50毫克雷尼替丁；25名患者静脉注射20毫克法莫替丁；45名健康男性作为对照组。测定所有受试男性血小板中超氧化物歧化酶活性、丙二醛浓度以及粒细胞中超氧阴离子生成情况。在给药前、给药后2小时和72小时进行超氧化物歧化酶活性和丙二醛浓度检测。在给药前和给药后2小时评估超氧阴离子生成情况。
我们的数据表明，所有检测的H2受体拮抗剂均刺激超氧化物歧化酶活性，但72小时后除丙二醛浓度降低外，还观察到明显升高。雷尼替丁和法莫替丁给药前后，溃疡病患者或健康受试者中超氧阴离子生成未观察到差异。仅在西咪替丁给药2小时后观察到超氧阴离子生成显著增加。
我们得出结论，H2受体拮抗剂对抗氧化过程具有有益作用。
