Czyzyk A, Lao B, Szutowski M, Szczepanik Z, Muszyński J
Department of Gastroenterology and Metabolic Diseases, Warsaw Medical School, Poland.
Arzneimittelforschung. 1997 Jun;47(6):746-9.
The oral ethanol loading test (0.5 g/kg body mass) was carried out in 3 groups with 10 healthy male volunteers each before and after 7 days of administration of either cimetidine (CAS 51481-61-9), ranitidine (CAS 66357-59-3), or famotidine (CAS 76824-35-6). The parameters determined during 6 h comprised the blood levels of ethanol, acetaldehyde, glucose, lactate, pyruvate and bicarbonates, as well as blood pH, PCO2 and PO2. Only ranitidine significantly increased the mean blood ethanol concentration and none of the drugs modified the blood acetaldehyde concentration. Hypoglycaemia following alcohol ingestion was significantly enhanced by all H2-receptor antagonists, but was most pronounced after famotidine. The alcohol-induced rise in blood pyruvate and lactate rather had a tendency to decrease during the second test. The presented results suggest that the evident enhancement of alcohol-induced hypoglycaemia by H2-receptor antagonists is not dependent on the increase of ethanol absorption from the gastrointestinal tract, but represents rather a specific effect of these drugs on glucose metabolism.
在给予西咪替丁（CAS 51481-61-9）、雷尼替丁（CAS 66357-59-3）或法莫替丁（CAS 76824-35-6）7天前后，对3组每组10名健康男性志愿者进行口服乙醇负荷试验（0.5 g/kg体重）。在6小时内测定的参数包括血液中的乙醇、乙醛、葡萄糖、乳酸、丙酮酸和碳酸氢盐水平，以及血液pH值、PCO2和PO2。只有雷尼替丁显著提高了平均血液乙醇浓度，且没有一种药物改变血液乙醛浓度。所有H2受体拮抗剂均显著增强了饮酒后的低血糖症，但法莫替丁作用最为明显。在第二次试验期间，酒精诱导的血液丙酮酸和乳酸升高反而有下降趋势。所呈现的结果表明，H2受体拮抗剂对酒精诱导的低血糖症的明显增强作用并非取决于胃肠道乙醇吸收的增加，而是这些药物对葡萄糖代谢的一种特定作用。
