Maiorano E, Favia G, Viale G
Institute of Pathological Anatomy and Dental Clinic, Centre for the Study of Oral Tumors, University of Bari School of Medicine, Italy.
Hum Pathol. 1998 Mar;29(3):260-5. doi: 10.1016/s0046-8177(98)90045-4.
An indolent lesion of the salivary glands that mimics Sjøgren syndrome has been repeatedly reported in HIV-infected (HIV+) patients. It is characterized by the occurrence, usually in the parotid gland, of variably sized lymphoepithelial cysts (LECs), whose origin is still unclear. We have compared the morphological and immunohistochemical features of six cases of LEC in HIV+ patients with those of five cases of LEC in HIV-negative (HIV-) patients. The results of the study show that LECs have similar histological and immunohistochemical features in both HIV+ and HIV- patients, and that they may simultaneously affect the salivary gland parenchyma and the intrasalivary lymph nodes. Furthermore, a diffuse lymphoid infiltrate is invariably observed in the glandular tissue around LECs and it is consistently associated with ectatic changes of the striated ducts. These data and the finding of an equivalent proliferation fraction of the epithelial compartment in both LEC and salivary retention cysts, used as controls for this study, are consistent with the hypothesis that cyst formation is secondary to the obstruction of salivary ducts by exuberant lymphoid infiltration.
在HIV感染（HIV+）患者中，一种类似干燥综合征的涎腺惰性病变已被多次报道。其特征是通常在腮腺出现大小不一的淋巴上皮囊肿（LEC），其起源尚不清楚。我们比较了6例HIV+患者的LEC与5例HIV阴性（HIV-）患者的LEC的形态学和免疫组化特征。研究结果表明，HIV+和HIV-患者的LEC具有相似的组织学和免疫组化特征，且它们可能同时累及涎腺实质和涎腺内淋巴结。此外，在LEC周围的腺组织中总是观察到弥漫性淋巴细胞浸润，并且它始终与纹状管的扩张改变相关。这些数据以及本研究中用作对照的LEC和涎腺潴留囊肿上皮成分增殖分数相当这一发现，与囊肿形成继发于旺盛的淋巴细胞浸润导致涎腺导管阻塞这一假说相符。
