Dolka Izabella, Tomaszewski Marek, Wola Daria, Czopowicz Michał, Kaba Jarosław
Department of Pathology and Veterinary Diagnostics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland.
The Scientific Society of Veterinary Medicine Students, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159, 02-787 Warsaw, Poland.
Animals (Basel). 2020 Sep 1;10(9):1545. doi: 10.3390/ani10091545.
The lymphoepithelial cyst (LEC) of the major salivary gland is a rare lesion described in medical literature. It is found in human immunodeficiency virus (HIV)-infected patients and considered an early manifestation of this infection. Despite the variety of theories, the origin of this lesion remains controversial. No veterinary studies on LEC have been published so far. This study is the first-ever that aims to describe histopathological, histochemical, and immunohistochemical features of a LEC located adjacent to the salivary gland of a goat. The goat proved seropositive for the small ruminant lentivirus, showed clinical signs of caprine arthritis-encephalitis, and had caprine arthritis-encephalitis virus (CAEV)-infected cells in the lung. The histopathology revealed a cystic lesion lined mainly with squamous epithelium surrounded by a lymphoid component, containing a mucus-negative material and a few nonbirefringent structures corresponding to amylase crystalloids. Using immunohistochemistry, CAEV-positive cells were detected in macrophages, LEC epithelial cells, and the salivary gland. The B cells were mainly in the germinal centres, the intraepithelial lymphocytes expressed CD3 and Bcl-2, and the proliferative activity was low. This study showed that LEC had many similar histological and immunohistochemical features to those seen in humans. However, further studies are required in this respect.
大唾液腺的淋巴上皮囊肿（LEC）是医学文献中描述的一种罕见病变。它在人类免疫缺陷病毒（HIV）感染患者中被发现，并被认为是这种感染的早期表现。尽管有多种理论，但这种病变的起源仍存在争议。迄今为止，尚未发表关于LEC的兽医研究。本研究是首次旨在描述山羊唾液腺旁LEC的组织病理学、组织化学和免疫组织化学特征的研究。这只山羊经检测小反刍兽慢病毒血清呈阳性，表现出山羊关节炎-脑炎的临床症状，且肺部存在山羊关节炎-脑炎病毒（CAEV）感染的细胞。组织病理学显示，一个囊性病变主要由鳞状上皮衬里，周围有淋巴样成分，含有黏液阴性物质和一些对应于淀粉酶晶体的非双折射结构。使用免疫组织化学方法，在巨噬细胞、LEC上皮细胞和唾液腺中检测到CAEV阳性细胞。B细胞主要位于生发中心，上皮内淋巴细胞表达CD3和Bcl-2，增殖活性较低。本研究表明，LEC具有许多与人类所见相似的组织学和免疫组织化学特征。然而，在这方面还需要进一步研究。
