Piattelli A, Corigliano M, Scarano A, Quaranta M
Dental School, University of Chieti, Italy.
Int J Periodontics Restorative Dent. 1997 Apr;17(2):162-9.
This pilot study analyzed the bone reactions to early loaded titanium plasma-sprayed implants. A total of 24 titanium plasma-sprayed implants (12 in the maxilla and 12 in the mandible) (Primary Healing Implant, Legnano) were inserted into four Macaca fascicularis monkeys with instruments specially designed to obtain a precise fit of the implant in the bone socket. A metal superstructure was cemented into 10 mandibular and 10 maxillary implants 15 days after implant insertion. The four remaining implants were used as controls. Eight months after implant placement, a block section was carried out, the defect was filled with nonresorbable hydroxyapatite, and all 24 implants were retrieved. The implants were treated to obtain thin ground sections that were examined under normal and polarized light. Histologic analysis showed that bone was observed around the implant surface in all implants. Morphometric analysis demonstrated that bone lined 67.2% (SD = 3.1%) of the maxillary implant surface, and 80.71% (SD = 4.6%) of the mandibular implant surface. No differences were found in the percentage of bone-implant contact in the control implants. In the loaded implants, however, the bone around the implants had a more compact appearance. The study demonstrated that it is possible to obtain a high percentage of bone-implant contact in early loaded titanium plasma-sprayed implants.
这项初步研究分析了早期负载的钛等离子喷涂种植体的骨反应。总共24颗钛等离子喷涂种植体（上颌12颗，下颌12颗）（Legnano的Primary Healing Implant）被植入4只猕猴体内，使用专门设计的器械以确保种植体在牙槽骨中精确就位。种植体植入15天后，在10颗下颌和10颗上颌种植体上粘结金属上部结构。其余4颗种植体用作对照。种植体植入8个月后，进行整块切片，缺损处用不可吸收的羟基磷灰石填充，然后取出所有24颗种植体。对种植体进行处理以获得薄磨片，在普通光和偏光下进行检查。组织学分析显示，所有种植体的植入体表面周围均观察到骨组织。形态计量学分析表明，上颌种植体表面67.2%（标准差=3.1%）有骨组织覆盖，下颌种植体表面80.71%（标准差=4.6%）有骨组织覆盖。对照种植体的骨-种植体接触百分比未发现差异。然而，在负载的种植体中植入体周围的骨组织外观更致密。该研究表明，在早期负载的钛等离子喷涂种植体中可以获得较高百分比的骨-种植体接触。
