Mizisin A P, Shelton G D, Wagner S, Rusbridge C, Powell H C
Department of Pathology, School of Medicine, University of California, San Diego, La Jolla 92093-0612, USA.
Acta Neuropathol. 1998 Feb;95(2):171-4. doi: 10.1007/s004010050783.
Nerve biopsy samples from two cats with spontaneously occurring diabetes were examined. The predominant nerve fiber abnormalities observed were restricted to the myelin sheath and Schwann cell. Reactive, degenerative and proliferative Schwann cell changes were evident but the most striking abnormality encountered was splitting and ballooning of the myelin sheath. These observations highlight the significance of Schwann cell injury in the pathogenesis of diabetic neuropathy.
对两只患有自发性糖尿病的猫的神经活检样本进行了检查。观察到的主要神经纤维异常仅限于髓鞘和施万细胞。施万细胞出现明显的反应性、退行性和增殖性变化，但最显著的异常是髓鞘的分裂和气球样变。这些观察结果突出了施万细胞损伤在糖尿病性神经病变发病机制中的重要性。
