单纯疱疹病毒2型的基因组序列。
The genome sequence of herpes simplex virus type 2.
作者信息
Dolan A, Jamieson F E, Cunningham C, Barnett B C, McGeoch D J
机构信息
MRC Virology Unit, Institute of Virology, Glasgow, United Kingdom.
出版信息
J Virol. 1998 Mar;72(3):2010-21. doi: 10.1128/JVI.72.3.2010-2021.1998.
Abstract
The genomic DNA sequence of herpes simplex virus type 2 (HSV-2) strain HG52 was determined as 154,746 bp with a G+C content of 70.4%. A total of 74 genes encoding distinct proteins was identified; three of these were each present in two copies, within major repeat elements of the genome. The HSV-2 gene set corresponds closely with that of HSV-1, and the HSV-2 sequence prompted several local revisions to the published HSV-1 sequence (D. J. McGeoch, M. A. Dalrymple, A. J. Davison, A. Dolan, M. C. Frame, D. McNab, L. J. Perry, J. E. Scott, and P. Taylor, J. Gen. Virol. 69:1531-1574, 1988). No compelling evidence for the existence of any additional protein-coding genes in HSV-2 was identified.
摘要
单纯疱疹病毒2型（HSV - 2）HG52株的基因组DNA序列测定为154,746 bp，G+C含量为70.4%。共鉴定出74个编码不同蛋白质的基因；其中三个基因在基因组的主要重复元件中各有两个拷贝。HSV - 2基因集与HSV - 1的基因集密切对应，HSV - 2序列促使对已发表的HSV - 1序列进行了几处局部修订（D. J. 麦吉奥克、M. A. 达尔林普尔、A. J. 戴维森、A. 多兰、M. C. 弗雷姆、D. 麦克纳布、L. J. 佩里、J. E. 斯科特和P. 泰勒，《普通病毒学杂志》69:1531 - 1574，1988年）。未发现有令人信服的证据表明HSV - 2中存在任何其他蛋白质编码基因。
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The product of the UL12.5 gene of herpes simplex virus type 1 is a capsid-associated nuclease.单纯疱疹病毒1型UL12.5基因的产物是一种与衣壳相关的核酸酶。
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Na, an autoproteolytic product of the herpes simplex virus type 1 protease, can functionally substitute for the assembly protein ICP35.钠是单纯疱疹病毒1型蛋白酶的一种自蛋白水解产物，它在功能上可替代装配蛋白ICP35。
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