Torii H, Ohnishi T, Matsuyama T, Harada S, Shishiba T, Watanabe S
Department of Dermatology, Kanto Communication Hospital, Tokyo, Japan.
Clin Exp Dermatol. 1997 Jul;22(4):183-8.
We report a 52-year-old female with trichogenic trichoblastoma arising on the supraclavicular fossa. Clinical and histological examinations revealed a thumbnail-sized, elastic, hard, subcutaneous nodule which consisted of keratinous cysts and epithelial cords of basaloid cells with focally follicular differentiation. Based on histological observations, a diagnosis of trichogenic trichoblastoma was made. An immunohistochemical study using a panel of monoclonal antibodies against cytokeratins was performed to investigate the nature and differentiation of this tumour. The most characteristic findings of the immunohistochemistry were CK 8 and 19 expression in the epithelial cords and the outer cells of the cystic structures. These immunoreactivities were similar to those of the outermost layer of the outer root sheath between the lower permanent portion and the upper transient portion, and immunostaining with the other antibodies confirmed this similarity. We can speculate that trichogenic trichoblastoma differentiates mainly toward the outermost layer of the outer root sheath between the lower permanent portion and the upper transient portion, and then into follicular structures.
我们报告了1例发生于锁骨上窝的毛发源性毛母细胞瘤的52岁女性患者。临床和组织学检查发现1个拇指指甲大小、质地坚韧、硬的皮下结节，由角质囊肿和具有局灶性毛囊分化的基底样细胞上皮索组成。基于组织学观察，诊断为毛发源性毛母细胞瘤。使用一组抗细胞角蛋白单克隆抗体进行免疫组织化学研究，以探究该肿瘤的性质和分化情况。免疫组织化学最具特征性的发现是上皮索和囊性结构外层细胞中细胞角蛋白8和19的表达。这些免疫反应性与下部永久性部分和上部过渡性部分之间外根鞘最外层的免疫反应性相似，用其他抗体进行免疫染色证实了这种相似性。我们可以推测，毛发源性毛母细胞瘤主要向下部永久性部分和上部过渡性部分之间外根鞘的最外层分化，然后分化为毛囊结构。
