Yamamoto O, Hisaoka M, Yasuda H, Nishio D, Asahi M
Department of Dermatology and Occupational Dermatopathology, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu.
J Cutan Pathol. 2000 Oct;27(9):460-5. doi: 10.1034/j.1600-0560.2000.027009460.x.
Since the first description by Hashimoto et al., there have been only a few case reports of rippled-pattern tricogenic tumor. In addition, there are no reports on detailed immunohistochemical analyses of this rare neoplasm. We describe here an additional case of rippled-pattern trichogenic tumor with a special reference to its immunohistochemical features.
A nodule arising on the occipital area of a 62-year-old Japanese woman was histologically and immunohistochemically investigated.
Histopathologically, the lesion contained various-sized lobular nests, which consisted of oval to elliptical shaped basaloid cells without any atypia and were embedded in the collagenous stroma. Some elongated basaloid cells were arranged in a palisading fashion forming parallel rows of epithelial ribbons in a rippled-pattern. Cytokeratin (CK) immunohistochemistry showed constant expressions of CK1/5/ 10/14, CK5/8, CK14 and CK7, and focal expressions of CK17 and CK19 in the basaloid cells, suggesting a keratin phenotypical similarity to the cells in small nodular type trichoblastoma.
The present tumor is a variant of trichoblastoma, and considered to be in close association with the outer root sheath and/ or follicular germinative cells.
自桥本等人首次描述以来，波纹状三基因肿瘤仅有少数病例报告。此外，关于这种罕见肿瘤的详细免疫组织化学分析尚无报道。我们在此描述一例波纹状毛囊源性肿瘤，并特别提及了其免疫组织化学特征。
对一名62岁日本女性枕部出现的结节进行了组织学和免疫组织化学研究。
组织病理学上，病变包含大小不一的小叶状巢团，由椭圆形至椭圆形的基底样细胞组成，无任何异型性，嵌入胶原性间质中。一些细长的基底样细胞呈栅栏状排列，形成波纹状的平行上皮带。细胞角蛋白（CK）免疫组织化学显示基底样细胞中CK1/5/10/14、CK5/8、CK14和CK7持续表达，CK17和CK19局灶性表达，提示其角蛋白表型与小结节型毛母细胞瘤中的细胞相似。
本肿瘤是毛母细胞瘤的一种变异型，被认为与外根鞘和/或毛囊生发细胞密切相关。
