Ohnishi T, Watanabe S
Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.
Am J Dermatopathol. 1999 Aug;21(4):337-43. doi: 10.1097/00000372-199908000-00005.
The immunophenotypes, especially expression of cytokeratins, in 13 cases of trichogenic tumors were examined to investigate their histogenesis. Four cases of multiple trichoepithelioma, five cases of classical solitary trichoepithelioma, one case of desmoplastic trichoepithelioma, one case of trichogenic trichoblastoma, one case of trichoblastic fibroma, and one case of giant solitary trichoepithelioma were retrieved. The immunoreactivities of the epithelial nests and the keratinous cysts in these tumors were similar to those of the outer root sheath and the infundibulum of normal hair follicles, respectively. From the comparative studies of the immunophenotypes with those of normal hair follicles, we speculated that all trichogenic tumors differentiate mainly toward the outermost layer of the outer root sheath between the lower part of the permanent portion and the upper part of the transient portion and some parts of them differentiate toward various other parts of the follicles. Although differentiation toward the other follicular structures can vary from case to case, there is no particular staining pattern specific for each kind of trichogenic tumor and no significant differences in immunoreactivity among them. Our observations support a recent notion that all neoplasms of follicular germinative cells should be grouped as a single entity.
对13例毛发源性肿瘤的免疫表型，尤其是细胞角蛋白的表达进行检测，以研究其组织发生。选取了4例多发性毛发上皮瘤、5例经典型孤立性毛发上皮瘤、1例促结缔组织增生性毛发上皮瘤、1例毛发源性毛母细胞瘤、1例毛母细胞性纤维瘤和1例巨大孤立性毛发上皮瘤。这些肿瘤中上皮巢和角质囊肿的免疫反应性分别与正常毛囊外根鞘和漏斗部的免疫反应性相似。通过对免疫表型与正常毛囊免疫表型的比较研究，我们推测所有毛发源性肿瘤主要向永久性部分下部和过渡性部分上部之间的外根鞘最外层分化，其中一些部分向毛囊的其他不同部位分化。尽管向其他毛囊结构的分化因病例而异，但没有针对每种毛发源性肿瘤的特定染色模式，它们之间的免疫反应性也没有显著差异。我们的观察结果支持了最近的一种观点，即所有毛囊生发细胞肿瘤应归为一个单一实体。
